Caveat: I haven't actually played this yet, but I'm excited to try it!
The rules and setting are very straightforward, requiring only a single d6 to play and filling less than 26 small pages. I've read through it a couple of times and have a copy printed out (booklet style) in my satchel awaiting it's moment as a pick-up game on short notice.
First thing to realize, this is a pretty straightforward traditional RPG, and although there are Horror checks and Willpower (embrace the madness), it's more about hitting Cthulhu in the face with a boat then subtle existential dread. Once you embrace this for what it is though, it looks great.
The rules should be quick and easy for just about anyone to pick up. It uses classes and levels, but don't look for splatbooks and hordes of special rules. The classes serve their purpose as classic archetypes for role-playing and to quickly and efficiently build a party of distinctive characters to shoot monsters in the face. Levels are fairly abstracted, allowing the game to support a longer campaign with increasing power levels without levelling tables and managing XP. This all supports the concept as a pick up and play game.
The Cthulhu Mythos serves mostly as a convenient shorthand to engage players in the world. Most long time gamers grok the tropes of Lovecraftian adventures, and as long as you realize this is on the pulpy side it works well. It would be trivially easy to reskin this for a more X-Files/Buffy Monster of the Week type game though if you are planning on using this with the uninitiated.
I'll revisit this review hopefully soon when I get a chance to try it out and see if I'm correct, but I'm expecting to be able to generate characters for a small party in under 10 minutes and take out a cult before the hour is up, assuming I have a single d6, some paper and pencils, and some wiling participants. That it also looks like it would support a long term campaign means it might make a great family travel game. You could probably play this well on a train, definitely a ferry.